In this report we review the status of a group of patients with neurosyphilis who were given fever therapy and who have now been under observation from three to five years. We will include, also, further observations on a smaller group of patients who were treated with nonspecific typhoid vaccine and who have been observed for two years.
Of the 213 patients treated between June, 1924, and June, 1926, 179 are available for this study. The remaining thirty-four have not been heard from for more than two years. One hundred of these patients, at the time they were inoculated with Plasmodium vivax, according to the suggestions of Wagner-Jauregg,1 had the early signs of paresis, although in a few the disease had progressed far enough to require institutional care. The majority had been under treatment for parenchymatous neurosyphilis for several years, long enough for the observation that the advance in
O'LEARY PA, BRUNSTING LA. THE NONSPECIFIC TREATMENT OF NEUROSYPHILISFIFTH ANNUAL REPORT. JAMA. 1930;94(7):452–454. doi:10.1001/jama.1930.02710330006002