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This is the product of one of the most fruitful combinations in medical work, the collaboration of the theoretical scientist with the clinician. In the introductory chapter the authors analyze the older theories concerning the nature and causes of prostatic hypertrophy; they deny the rationality of the term prostatism, refute the interpretation of prostatic hypertrophy as a compensatory or inflammatory reaction, and assert that the type of this tumefaction is glandular, and that this glandular hyperplasia originates in rudimentary glands. Hyperplasia is the primary factor; the changes in the fibrous skeleton are secondary. The variations in the microscopic pictures are explained by the fact that in this neoplasm of the prostate new formation of tissue and regressive metamorphosis occur simultaneously. It is declared to be still an open question whether prostatic hypertrophy is to be considered a true neoplasm or a hyperplasia. Tandler and Zuckerkandl have proved that prostatic hypertrophy
Studien zur Anatomie und Klinik der Prostatahypertrophie.. JAMA. 1923;80(9):649. doi:10.1001/jama.1923.02640360057033