December 6, 1924


JAMA. 1924;83(23):1861-1862. doi:10.1001/jama.1924.02660230055022

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Antidiphtheric Vaccination  A number of papers were recently presented at a meeting of the Société belge de biologie that are deserving of attention. Henseval and Nélis discussed the results of the use on man and animals of Ramon's new vaccine, anatoxin. The rabbit is completely immunized by it. Likewise, vaccinations applied to children have given excellent results. Henseval and Nélis attribute the good results to the fact that in the anatoxin a large quantity of substances termed "toxoids" are found, which are capable of neutralizing antitoxin without presenting the least toxicity. M. De Potter communicated the results of attempts at antidiphtheric vaccination by means of heated toxin. Vaccination is accomplished—though quite slowly—when toxin heated at a temperature of 80 C. for twenty minutes is employed. In toxin heated to this temperature, De Potter was unable to discover any appreciable quantity of toxoids. He inclines to the belief that the antigenic

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