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Herpes zoster belongs in the category of diseases that cause severe pain, especially when it occurs in individuals of mature or advanced age. The pain may start before, during or after the appearance of the vesicles, and may persist almost without remission for weeks or months. Pain of this type is difficult to alleviate with anything milder than morphin. For this reason, any remedy that offers relief in a fair number of cases should be gratefully accepted by the patient. In epinephrin we have a remedy that will temporarily relieve the pain in a majority of cases. My use of epinephrin in the treatment of herpes zoster was based on an observation of a case of hives and angioneurotic edema in a patient who had recently weaned a baby. About one hour before I saw her, there had appeared about fifteen or twenty vesicles on the lower lip, associated with
Duke WW. EPINEPHRIN IN THE TREATMENT OF THE PAIN OF HERPES ZOSTER. JAMA. 1924;83(24):1919. doi:10.1001/jama.1924.26610240001011a