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Mackenzie's views on angina pectoris are well known to most readers. In this work they are restated and elaborated at length. Briefly, he believes that the complex of symptoms called angina pectoris is due to the contraction of heart muscle: an unduly strong contraction, a contraction when the blood supply is insufficient, or one when the muscle is exhausted. His theory is, in reality, a modified coronary artery theory. What he calls secondary angina pectoris, the pseudo-angina of many older writers, is due to a hypersensitive state of the nervous system and not to any organic disease in the heart as is his primary angina, the form often spoken of as true angina. There is a pleasing, broadly philosophical tone to the work, which is concerned not so much with trivial details as with a study of fundamentals, such as the importance of symptoms, the mechanism and significance of pain,
Angina Pectoris.. JAMA. 1924;83(24):1945. doi:10.1001/jama.1924.02660240059034