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February 22, 1930

Ueber freien und gebundenen Zucker in Blut und Organen.

JAMA. 1930;94(8):584. doi:10.1001/jama.1930.02710340062033

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This is a compilation and organization of our present knowledge of a rather obscure subject. In it, what is known of the nature and quantitative variations of the bound sugar of the blood and tissues is clearly and systematically reviewed. By bound sugar is meant that reducing substance, over and above the blood sugar and nonfermentable reducing substances, which appears when blood is hydrolyzed in the presence of dilute acid. The author takes pains to point out that only a part of this additional reducing substance may be considered to be present in hexose form. He therefore suggests the less exclusive term "hydrolyzable substance" (abbreviated to Hy-S). The relative constancy of the hydrolyzable substance of the blood as determined by any given method on a particular species, and its quantitative variation under different physiologic, pathologic and experimental conditions, give rise to some fascinating speculations. The author stresses the fact that

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