The keynote of the modern diagnosis of neoplasms is the recognition of many distinct clinical and pathologic entities in the vast field of benign and malignant tumors. It is no longer possible to content oneself with the simple report that the case is carcinoma or sarcoma. It is necessary to know what exact type of carcinoma or sarcoma is present, what the extent of the disease may be, what degree of malignancy is concerned, and what the natural history of the disease will reveal. In other words, it is necessary for the pathologist and clinician to form a clinical diagnosis and not rest merely on a histologic report.
The introduction of radiation treatment has emphasized the importance of the finer diagnosis of tumors, for without accurate knowledge of the structure and natural course of the disease, the radiologist is seriously handicapped. The surgeon also needs such knowledge for the intelligent
EWING J. THE DIAGNOSIS OF CANCER. JAMA. 1925;84(1):1-4. doi:10.1001/jama.1925.02660270005001