An intensive stimulus to biologic inquiry has been given to neuropsychiatry since epidemic encephalitis made evident the need of a recasting of clinical modalities and their interpretations with reference to pathologic findings.
The psychotic manifestations of encephalitis, those that accompany or are a part of the acute illness, are now definitely recognized as of the nature of acute organic reactions; that is to say, are of the type of psychic symptoms produced in the deliria of etiologically toxic basis. In nearly all cases of epidemic encephalitis, there seems to be, at least in some degree, an involvement of the psyche. The form and degree of clouding of the sensorium in more profound cases vary from active deliria to stupor and even profound coma. The so-called occupational delirium, as is well known, is more often seen, and the tendency to "push of talk" is more frequent in epidemic encephalitis than in
GOODHART SP, COTTRELL SS. RESIDUA AND SEQUELAE OF EPIDEMIC ENCEPHALITIS. JAMA. 1925;84(1):32-36. doi:10.1001/jama.1925.02660270036011