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January 3, 1925

THE BACTERIOPHAGE

JAMA. 1925;84(1):39-40. doi:10.1001/jama.1925.02660270043016
Abstract

The assumption by d'Herelle 1 of an ultramicroscopic filtrable parasite, Bacteriophagum intestinale, as the cause of the "clearing" or lysis of certain bacterial cultures after their inoculation with seemingly sterile filtrates of dysentery stools has been a special stimulus to the study of this reaction. Articles under such titles as bacteriolysants, transmissible lysin, the d'Herelle or the Twort-d'Herelle phenomenon, and the bacteriophage have since described lytic reactions obtained not only from filtrates of stools, but also from river water, pus, urine, exudates and tissue extracts, old cultures, normal cultures or their sensitive variants, and other sources. The staphylococcus and other organisms as well as the members of the typhoid-dysentery-coli group have been found susceptible to lysis with a variable degree of specificity and with the occurrence in each group of resistant strains. Many investigators find no evidence for a living bacteriophage, yet none can state that the theory is actually

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