March 1, 1930


Author Affiliations

Pasadena, Calif.

JAMA. 1930;94(9):653. doi:10.1001/jama.1930.02710350053025

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To the Editor:  —In regard to the communication of Drs. Coffey and Humber (The Journal, February 1, p. 359) announcing the effect of an extract of the suprarenal cortex on malignant tissue, I have observed the same effects, namely, liquefaction, necrosis and sloughing, together with new capillary growth, on administration of an extract from the omentum of the pig. I announced this remedy to the Pasadena Branch of the Los Angeles County Medical Society, April 17, 1928. It has subsequently been in use in the wards of the Los Angeles General Hospital for more than a year.Furthermore, I have identified my extract as containing the active principle of the reticulo-endothelial system through its action on bile formation. Ranvier first described the omental portion of the reticulo-endothelial system more than fifty years ago. This substance has, accordingly, been given the name of "reticulin." It is an enzyme which digests the

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