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Clinical Trials Update
June 23/30, 2015

Mindfulness Therapy Is Not Superior to Maintenance Antidepressants

JAMA. 2015;313(24):2416. doi:10.1001/jama.2015.6588

Mindfulness-based cognitive therapy (MBCT) is as effective as maintenance antidepressant treatment in preventing depression relapse, suggest results from a recent randomized trial (Kuyken W et al. Lancet. doi:10.1016/S0140-6736(14)62222-4 [published online April 20, 2015]).

Trial participants were recruited from primary care practices in England and included 424 adults who had been diagnosed with recurrent major depressive disorder in full or partial remission based on Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV) criteria, had 3 or more previous major depressive episodes, and were taking a therapeutic dose of maintenance antidepressants. Participants were randomly assigned in a 1:1 ratio to taper or discontinue their antidepressants and receive MBCT or to continue taking their medication for 2 years.

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