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March 8, 1930


JAMA. 1930;94(10):729-730. doi:10.1001/jama.1930.02710360053019

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The Filtrable Tuberculosis Virus  Several interesting observations have recently been made on the subject of the tuberculosis virus in the filtrates of bacillus cultures and containing apparently invisible spores. J. Valtis and A. Soenz cultivated tubercle bacilli on Sauton's synthetic medium, and this culture, when fifteen days old, was filtered through a porcelain filter and implanted in 1 cc. doses in a special fluid medium. In a very short time, there developed, in the latter, acid-resistant tubercle bacilli. What is peculiar is that these bacilli are not transplantable in a series, and do not manifest any virulence when injected into the guinea-pig. The second culture inoculated into the rabbit intravenously causes the prompt appearance of toxic phenomena, with paraplegia or paralysis of the four limbs, opisthotonos and often death in twenty-four hours. It is thus proved that the filtrates of bacillus cultures may, under certain conditions, give rise to other

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