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June 9, 1923


JAMA. 1923;80(23):1695-1696. doi:10.1001/jama.1923.02640500037015

The discovery by Osborne and Mendel, some years ago, that cod liver oil is rich in one of those essentials of nutrition now designated as vitamins, has given a new scientific dignity to a product long used in an empiric way for therapeutic ends. This interesting finding has naturally led to more intensive investigation, not only of cod liver oil itself, but also of many other animal and vegetable oils since demonstrated to be carriers of such physiologic potencies. There is considerable evidence already accumulated to show that the property currently designated as vitamin A is not entirely destroyed by saponification of the oils, whereby the fats lose their identity as such. Several investigators have already separated from cod liver oil nonsaponifiable fractions in which some, at least, of the effective component is concentrated in very small bulk. The sources of potent fish oils and the factors that affect the

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