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June 9, 1923


JAMA. 1923;80(23):1696-1697. doi:10.1001/jama.1923.02640500038016

The recent development of the physiology of nutrition has placed the significance of the blood proteins in a new light. Before the period when the amino-acids acquired their dominance as the primary nitrogenous nutrients of the organism, a comparable importance was assigned to the blood proteins. It was assumed— for, assuredly, it was not proved—that the products of the digestion of protein were somehow converted during their passage through the alimentary wall into serum proteins. Thus it seemed as if the tissues drew on the blood proteins for their nitrogenous nutrients and that the supply of serum proteins became replenished after each meal containing albuminous substances. All of this edifice of hypotheses was shattered by the demonstration that the amino-acids are apparently not immediately synthesized into blood proteins after their absorption from the gastro-enteric tract. The physiologist, furthermore, has now found himself face to face with the problem of ascertaining

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