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March 7, 1925


Author Affiliations

Havana, Cuba.

JAMA. 1925;84(10):770. doi:10.1001/jama.1925.02660360052028

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To the Editor:  —In the article that Dr. Joseph F. Wearn contributes to "Glandular Therapy" (The Journal, Nov. 8, 1924, p. 1508), I note a flagrant contradiction between two assertions:In conditions in which there exist a weak failing heart action and lowered blood pressure but no increase in capillary permeability, epinephrin is an excellent cardiovascular stimulant. An example of such a condition is the collapse that sometimes follows excessive anesthesia.The use of epinephrin either during or immediately after chloroform anesthesia is distinctly contraindicated because of the frequency of ventricular fibrillation and death following the combination of these two drugs.[The matter was referred to Dr. Wearn, who replies:]

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