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Complement Fixation Test on Cerebrospinal Fluid of Lepers
A paper on the deviation of complement in leprosy was presented before the Society of Biology of Rio de Janeiro by Drs. J. M. Gomes, Adhelbar Tolosa, Fleury da Silveira and Azevedo Antunes. They used, as an antigen, Deycke's defatted leprous bacillus. Some time ago the authors observed that lepers (especially those with leprosy of the nervous system) have a positive reaction of the cerebrospinal fluid, while some of the same patients have a negative reaction of the blood serum. The authors have made a study in which the cerebrospinal fluid, used as control, was from patients with well known nervous diseases. Dr. Nestor Solano, head of the Instituto Aché, furnished them with the cerebrospinal fluid of several patients with nervous diseases, in none of whom leprosy was suspected. In all these specimens the reaction was negative. The authors believe that this
RIO DE JANEIRO. JAMA. 1930;94(13):1007-1008. doi:10.1001/jama.1930.02710390105018