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July 21, 1923


JAMA. 1923;81(3):228. doi:10.1001/jama.1923.02650030052023

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The Expiration of Immunity Against Rabies  Professor Szekely, director of the Budapest Pasteur Institute, in an address recently before the Royal Medical Society, said that it often happens that a person previously bitten and inoculated is subsequently again bitten by a mad dog. The question then naturally arises whether he should be inoculated de novo against rabies or whether revaccination is superfluous, the first inoculation having afforded immunity against further infection. The same question presents itself also in regard to smallpox. Before giving an answer to this important and at present much discussed practical question, we must first decide how long the immunity artificially produced by inoculation lasts. Does it last for life or does it lapse after a certain time? In the latter case, obviously, we ought to inoculate anew if we desire to obviate an imminent risk. Jenner himself held the opinion that immunity once produced against smallpox

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