It seems worth while to record the results of some observations of cases in which certain constitutional disorders apparently have been caused by suppurative disease in the paranasal sinuses. The cases to be discussed include those of children and adults.
Until recently, there have been only a few physicians who have attached much importance to sinus disease in children because of the generally prevalent idea that in children the sinuses are in such a rudimentary stage of development as to be negligible clinically.
The experiences of Dean,1 Sluder,2 Lemere3 and other investigators, as well as my own, have thoroughly convinced me that, in many instances, the portal of entry of many of the more serious ailments of infancy and childhood has been entirely overlooked. Furthermore, I am convinced that a large proportion of cases of chronic nasal disease of adult life, with the attendant constitutional manifestations, have
ARBUCKLE MF. SYSTEMIC MANIFESTATIONS OF SUPPURATIVE DISEASE IN PARANASAL SINUSES. JAMA. 1923;81(9):741-744. doi:10.1001/jama.1923.02650090039011