Analysis of the vast amount of literature accumulated on the subject of essential hypertension makes it evident that many investigators share the opinion of Bell and Clawson,1 who think that a uniform explanation of this clinical syndrome cannot be upheld at the present stage of our knowledge. Regardless of the cause, however, the mechanism is generally considered to be a vascular contraction, with some exciting agent producing the spasm. Some2 assume a "hypothetic pressure substance" to be present in the blood, which contracts the wall of the arterioles. Others3 are inclined to believe in a disturbance of the sympathetic nervous system as the main etiologic factor.
While capillary spasm has thus been identified with hypertension, a number of clinicians working in the field of allergy hold that a similar mechanism is responsible for certain manifestations of allergy. Vaughan4 states that "angiospasm is the characteristic phenomen of
WALDBOTT GL. HYPERTENSION ASSOCIATED WITH ALLERGY. JAMA. 1930;94(18):1390–1392. doi:10.1001/jama.1930.02710440028009