This is a report of three cases of Paget's disease of the nipple in which each affected breast presented a true intraduct carcinoma, as shown on microscopic study of serial sections. There were no palpable tumors in these mammary glands. It is significant that the lesion on the nipple of one of these carcinomatous breasts was of only one month's duration.
Our observations in these cases substantiate the reports of Cheatle,1 Pautrier,2 Fraser3 and others who gave cogent reasons for removing Paget's disease of the nipple from the realm of the "so-called precancerous dermatoses" and putting it in the class of a true cancer. Paget's disease of the nipple is most frequently seen in women over 40 and is usually unilateral. Most often it begins as a mild eczematoid condition of the nipple which may spread over the areola and even part of the breast. Later it
ELLER JJ, ANDERSON NP. PAGET'S DISEASE OF THE NIPPLEA MANIFESTATION OF INTRADUCT CANCER: REPORT OF THREE CASES. JAMA. 1930;94(21):1653–1655. doi:10.1001/jama.1930.02710470017008