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November 10, 1923


JAMA. 1923;81(19):1612-1613. doi:10.1001/jama.1923.02650190042019

Since Quincke, in 1890, published the technic of lumbar puncture, our knowledge of the condition of the spinal fluid in various pathologic states has increased greatly, until now this procedure has become almost a routine in the examination of cases of nervous disease. Under certain conditions the fluid may be yellow instead of colorless, this, according to Scully,1 having been reported first in 1897 by Busch and shortly after by Schroeder. In 1903, Froin 2 described a combination of yellowness, spontaneous coagulation soon after withdrawal, and lymphocytosis, which has since come to be known as Froin's syndrome. It has been observed in connection with diseases, such as intraspinal tumors and adhesions from meningitis, that obstruct the spinal canal and interfere with the circulation of the fluid. The syndrome is not always complete; lymphocytosis may be absent, and coagulation may be slight or delayed. Nonne has shown also that in

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