Since the original statement of Lösch concerning disease-causing amebas, there has been discussion and dispute, first, as to whether these organisms actually caused the clinical symptoms and pathologic changes with which they were charged; secondly, as to their classification, differentiation and pathogenicity; thirdly, their nomenclature, various phases of their life cycle, cultivability and methods of transmission; and, finally, these points of dispute having been reasonably well settled, there still seems considerable difference of opinion as to the geographic distribution of the organism and as to whether the clinical manifestations of the disease caused by Endameba histolytica are modified by location or whether the disease in temperate climes may be caused by an organism morphologically indistinguishable from E. histolytica, but less toxic in its action. Further, doubters are not few among clinicians and even among laboratory workers of limited experience who charge that the harmless E. coli is often miscalled E.
DOWLING GA. AMEBIC INFECTION IN THE STATE OF WASHINGTON. JAMA. 1923;81(20):1657-1661. doi:10.1001/jama.1923.02650200007002