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Article
September 12, 1925

THE UNKNOWN DETERMINING FACTORS IN DISEASES OF THE NERVOUS SYSTEM

JAMA. 1925;85(11):787-790. doi:10.1001/jama.1925.02670110001001
Abstract

Our knowledge of the etiology and the pathogenesis of disease processes is steadily advancing, thanks to the constant accessions of new workers in laboratories throughout the world; and tremendous strides are being constantly made in the advancement of our knowledge of the physical and chemical forces at work in living organisms. As the questions about which fierce controversies raged—it seems only a few years ago—are answered, other questions present themselves with a new significance, in an entirely different light, are just as puzzling, demand even greater concentration of thought, and appear to hold out the same elusive will-o'-the-wisp promise of solution that formerly mocked us in problems which at present no longer exist.

It seems only a short while ago when arguments pro and con were being hurled back and forth over the possibility of tabes and paresis without syphilis. When Erb, Fournier and a few others fought with almost

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