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September 12, 1925


JAMA. 1925;85(11):826-827. doi:10.1001/jama.1925.02670110040013

The first detailed report of a long projected experiment on the vaccination of monkeys against tuberculosis in their native environment has recently been published. From time to time1 there have appeared in French medical literature accounts of research on the immunizing power of a bacillary vaccine, prepared by Calmette and Guérin, and called for simplicity BCG. This vaccine consists of tubercle bacilli greatly reduced in virulence by prolonged cultivation on potato or agar saturated with bile containing 5 per cent. glycerol. Calmette and Guérin have repeatedly asserted that this vaccine confers immunity without producing anatomic tubercle. According to Calmette,2 the only effect of massive injection of this bacillus is "general disease which is like typhoid fever and which cures itself spontaneously after fifteen to twenty days without producing the slightest tubercle formation." Yet calves, guinea-pigs, rabbits and monkeys treated with doses of a few milligrams of the substance,

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