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Article
September 12, 1925

THE METABOLIC DIFFERENCES BETWEEN CANCER CELLS AND NORMAL CELLS

JAMA. 1925;85(11):827-829. doi:10.1001/jama.1925.02670110041015
Abstract

While the pathologists have been looking for either a specific exciting cause or a specific diagnostic reaction for cancer, the biochemists have been searching for some characteristic chemical or functional peculiarity in the cancer cells that might explain their behavior, and perhaps their pathogenesis. For the most part the efforts of both groups of investigators have been unsuccessful. Such methods as we have for tissue analysis have failed to show wherein cancer cells differ from the cells from which they have taken their origin. This is not surprising in view of the relative crudeness of the available methods and the fact that they concern themselves merely with the dead protoplasm and not with the living cells. Furthermore, even such a refined immunologic method as the complement fixation test fails to disclose the presence in cancer of any protein or other antigenic substance that is peculiar to cancer tissue. That no

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