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This comprehensive work is the result of the collaboration of many authorities and is intended as a reference volume not only for syphilologists and physicians but for chemists and chemotherapeutists as well. The history of the pioneer work in chemotherapy is given in great detail, together with the development of the arsenical derivatives in the experimental work with the trypanosomes. The pharmacology and toxicology of the arsphenamins is well treated, as also is the therapeutic activity and the biologic testing of the various preparations. A chapter is devoted to the chemistry of the arsenicals and another to the fate of the arsphenamins when introduced into the body by the various routes. Other chapters are devoted to the methods and technic of intravenous medication; the therapeutic application of arsphenamin in man; the course of syphilis under such treatment, and the treatment of syphilis with arsphenamin alone and combined with mercury. The
Handbuch der Salvarsantherapie mit Einschluss der experimentellen, biologischen und chemischen Grundlagen.. JAMA. 1925;85(11):846. doi:10.1001/jama.1925.02670110060031