September 26, 1925


JAMA. 1925;85(13):995-996. doi:10.1001/jama.1925.02670130057028

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To the Editor:  —In view of the definite increase in the number of cases of infantile paralysis in the various parts of the country this summer, it may be of interest to know that serum from patients who have recovered has been used recently with several satisfactory results. A child, aged 4½ years, developed typical preparalytic symptoms; a lumbar puncture was done and spinal fluid containing 500 cells to the cubic millimeter was found. At the time of the puncture the patient had a temperature of 102, was toxic and showed the typical muscular twitchings that belong to this stage of the disease and indicate the penetration of the central nervous system by the virus. Fifteen cubic centimeters of serum from a patient who had recovered was run into the spinal canal, and immediately thereafter 50 c.c. was given intravenously. At the end of four and a half hours a

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