The demonstration that placental transmission of tuberculosis rarely occurs in cattle at once suggested to the dairy industry a practical method of control of tuberculosis by immediate separation of new-born calves from infected mothers. A strict application of postnatal quarantine, however, was found impracticable. Calves isolated at birth from infected mothers and placed on an artificial diet develop diarrhea, exudative arthritis and inflammation of the umbilical stump, which usually end fatally within a week. In spite of great care, Smith and Little1 were unable to rear more than one calf out of six after early segregation. Pathologic examination of quarantined calves dying during the first week showed death usually due to fulminating infection with Bacillus coli or with other environmental micro-organisms usually classed as harmless saprophytes. Apparently the new-born calf is wholly lacking in the normal adult defense against these micro-organisms.
A less rigid quarantine, however, is practicable, though,
COLOSTRUM ANTIBODIES. JAMA. 1930;94(24):1922-1923. doi:10.1001/jama.1930.02710500040017