June 14, 1930


JAMA. 1930;94(24):1933-1934. doi:10.1001/jama.1930.02710500051027

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Deaths Following Inoculation with B C G Vaccine  On the basis of numerous observations and reports, a number of immunizing inoculations against tuberculosis after the method of the French investigator Calmette have been made in Lübeck. In July, 1929, a culture was obtained from Professor Calmette and was recultivated, at intervals of four weeks, in Lübeck. The inoculations and the preparation of the vaccine emulsions were carried out in Lübeck under the personal supervision of Professor Deyke, phthisiologist and director of the Allgemeines Krankenhaus. According to information given out by the public health service of Lübeck, the cultures for the inoculations were subjected to animal experimentation as a safeguard, before they were given out. A total of 246 children were inoculated. April 26, 1930, one death and four cases of infection among the inoculated infants were reported to the health service of Lübeck, whereupon no further vaccine emulsions were given

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