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June 21, 1930


JAMA. 1930;94(25):2015. doi:10.1001/jama.1930.02710510053025

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To the Editor:  —In The Journal, May 24, there appeared an article entitled "Myocardosis," by Drs. Albert S. Hyman and Aaron E. Parsonnet. This article attracted my attention because, about two years ago, I thought of using that term to designate a certain group of anatomicopathologic states of the heart characterized by acute or subacute degenerative processes, such as granular, hyaline and fatty degeneration, caused, occasionally, by constitutional infections or intoxication. Such a term offers a correct classification of this group as distinguished from acute, subacute and chronic inflammatory processes, and from fibrotic degeneration of the myocardium. Moreover, it corresponds exactly pathologically to the true meaning of nephrosis from which the authors draw their analogy, as used in degenerative nephropathies according to the following classification of Fahr:

  • Simple nephrosis:

    • First stage: albuminous degeneration.

    • Second stage: hyaline degeneration.

    • Third stage: necrosis (mercury poisoning).

  • Distinctly characterized nephrosis:

    • Lipoid nephrosis.

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