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October 31, 1925


JAMA. 1925;85(18):1402-1403. doi:10.1001/jama.1925.02670180058019

The much debated problem of the extrahepatic formation of bile pigment, to which reference has repeatedly been made in The Journal,4 has found its solution in the positive demonstration that the liver is not essential to the production of bilirubin. Perhaps the most convincing evidence has been furnished by Mann's experiments at the Mayo Clinic, wherein it was observed that in the urine, blood plasma and fat of totally dehepatized dogs a yellow pigment appears which gives a positive reaction to all the accepted chemical tests for bilirubin. More recently, Mann, Sheard and Bollman5 have made the evidence for the identity of the yellow pigment even more convincing. They have determined the curve of light transmission of the pigment and compared the curves obtained with the bilirubin in the plasma of a control dog having the common bile duct obstructed and gallbladder excised, with the curve produced by

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