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June 28, 1930


JAMA. 1930;94(26):2084. doi:10.1001/jama.1930.02710520050024

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To the Editor:  —I have read with keen interest your editorial, May 31, entitled "Experimental Nephrosis," in which you discuss the excellent contribution to this subject by Drs. Barker and Kirk. Because of the great medical public reached by The Journal, only a fraction of which has ready access to the original papers, I deem it desirable in the interest of historical accuracy to point out the following facts:

  1. The observations of Drs. Barker and Kirk constitute a desirable experimental verification of conclusions reached fifteen years ago on the basis of clinical and chemical studies by Dr. A. A. Epstein (J. Exper. Med. 16:719, 1912; The Journal, Aug. 11, 1917, p. 444; Am. J. M. Sc. 154:638 [Nov.] 1917), and since championed by him in numerous publications and addresses. Dr. Epstein has published his views on the significance of hypoproteinemia for the pathogenesis of nephrotic edema on so many

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