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Article
February 9, 1924

SPECIFICITY OF STREPTOCOCCI IN ETIOLOGY OF DISEASES OF NERVOUS SYSTEM

JAMA. 1924;82(6):449-453. doi:10.1001/jama.1924.02650320019007
Abstract

During an extended study of the infecting power of bacteria isolated in various diseases, I have been impressed by the extremely specific effects of green-producing streptococci, especially those isolated from infection atria, and from the brain and cord in diseases of the nervous system. Herpes zoster, associated with lesions in the interverbral ganglions, was produced in rabbits and dogs by intravenous injection of a green-producing streptococcus from infection atria in patients at the time of acute attacks. This was not accomplished after recovery, nor after long cultivation of the organism. A similar streptococcus from four patients with intercostal neuralgia produced marked lesions of the posterior or sensory roots, usually unassociated with herpes, on intravenous injection in rabbits. A gieen-producing streptococcus obtained on two occasions from infected tonsils and teeth of a patient with severe multiple neuritis showed marked affinity for nerves, especially peripheral nerves, in three species of animals, a

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