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Renal cell carcinomas (RCCs) are addicted to the amino acid glutamine, and inhibiting glutamine metabolism by blocking glutaminase can slow tumor progression—at least in mice (Shroff EH et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1507228112 [published online May 11, 2015]). Most patients who present with advanced RCC have a poor prognosis, and a lack of transgenic models of RCC has made it difficult for scientists to develop new therapies.
Hampton T. Blocking Glutamine Metabolism Shrinks Kidney Cancers in Mice. JAMA. 2015;314(1):16. doi:10.1001/jama.2015.7175