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Lab Reports
July 7, 2015

Blocking Glutamine Metabolism Shrinks Kidney Cancers in Mice

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Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;314(1):16. doi:10.1001/jama.2015.7175

Renal cell carcinomas (RCCs) are addicted to the amino acid glutamine, and inhibiting glutamine metabolism by blocking glutaminase can slow tumor progression—at least in mice (Shroff EH et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1507228112 [published online May 11, 2015]). Most patients who present with advanced RCC have a poor prognosis, and a lack of transgenic models of RCC has made it difficult for scientists to develop new therapies.

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