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February 9, 1924

Laboratory Diagnosis of Syphilis. A Manual for Students and Physicians.

Author Affiliations

By Hideyo Noguchi, M.D., M.S., Ph.D., Member of the Rockefeller Institute for Medical Research. Cloth. Price, $7.50. Pp. with 59 illustrations. New York: Paul B. Hoeber, Inc., 1923.

JAMA. 1924;82(6):493. doi:10.1001/jama.1924.02650320063037

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In the early days of the Wassermann test, Noguchi wrote the "Serum Diagnosis of Syphilis." That book introduced a modification of the original Wassermann technic which was a factor in establishing the value of the Wassermann test. The "Laboratory Diagnosis of Syphilis" covers the same ground as the older book, and has an added chapter. In the decade that has intervened between these publications, Noguchi has made no fundamental changes in technic, and he says concerning the attempts to standardize the Wassermann reaction that no amount of accuracy in complement, antigen and other factors will be of any value as long as the amboceptor is not quantitatively adjustable. The various precipitation tests that have been devised in recent years are not described in this book in detail, for the author considers that their usefulness has not been established. Noguchi still considers the luetin reaction a valuable diagnostic aid, particularly in

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