The intraperitoneal administration of fluids, such as physiologic sodium chlorid solution,1 glucose,2 and sodium bicarbonate,3 in the treatment of the diarrheas and the acidoses of infancy, is already established as the method of choice in certain selected instances in which the usual procedures of intravenous, intramuscular and subcutaneous injections are not practical, for well known reasons. Transfusion4 by the intraperitoneal route has recently been revived, and is now used in the treatment of certain conditions in infancy.
That the peritoneum serves as an absorbing membrane can no longer be questioned. However, in intra-peritoneal therapy, it is essential to determine the reaction on the part of the peritoneum to the solution administered, as this reaction varies under certain definite conditions and may result in temporary or permanent injury of the mesothelial cells. Should permanent injury of the mesothelial cells occur, as is evidenced by failure of the
ROSENBERG W. THE INTRAPERITONEAL ADMINISTRATION OF NEO-ARSPHENAMINPRELIMINARY REPORT. JAMA. 1924;82(9):682–684. doi:10.1001/jama.1924.02650350014004