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July 12, 1930


JAMA. 1930;95(2):141-142. doi:10.1001/jama.1930.02720020057024

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Hereditary Influences in Cancer Transmission  At the suggestion of American cancer research workers who, for years, have studied tens of thousands of mice to discover the possibility of the hereditary transmission of cancer, Professor Bernstein, of the chair of mathematical statistics in Göttingen, and Siegfried Koller, made a statistical analysis of the published genealogical trees and the original records of experiments. Bernstein reported before the Berliner Medizinische Gesellschaft that the analysis led to the conviction that cancer of the breast in mice is of hereditary origin and that strains of mice with high and low percentages of cancer may be distinguished; also that the localization of the primary tumor, and the susceptibility of certain organs to metastases, are subject to hereditary influences. In view of the fact that the hereditary conditions of cancer are, in principle, much the same as the hereditary conditions of other inherited diseases, Bernstein holds that

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