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July 26, 1930


JAMA. 1930;95(4):269-270. doi:10.1001/jama.1930.02720040027011

Although much progress has been made in recent years with regard to the changes that carbohydrates and proteins undergo in the chemical transformations within the organism, our knowledge of the metabolism of fats remains quite scanty. When one recalls the fact that fats form a large part of the energy intake of man, the paucity of information regarding the metabolic fate becomes the more regrettable. In the case of the carbohydrates, interest has become centered on the reactions of dextrose and glycogen, which are the compounds of main physiologic moment. Other hexose carbohydrates are for the most part converted into them before they engage in the functions of the tissues. Carbohydrates that do not experieince this effect tend to play a minor part.4 The proteins present a more complex problem in that they reappear in the circulation in the form of eighteen or twenty amino-acid fragments or simple polypeptides,

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