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August 2, 1930


JAMA. 1930;95(5):344-345. doi:10.1001/jama.1930.02720050032012

The development of the theories of diabetes has not kept pace with our knowledge of the principal features of the disease and the effective methods of its management. Certain facts are dominant in their significance. Hyperglycemia and glycosuria represent abnormalities that always demand clinical consideration. What are their underlying causes? It is on this question that considerable disagreement exists among investigators at present. As Soskin1 has pointed out, one group has long advocated the overproduction theory of diabetes, which, in its simplest terms, attributes the glycosuria and hyperglycemia of diabetes not to a defect in oxidation of carbohydrates but rather to an overproduction of dextrose from protein and fat, which causes its accumulation in spite of a continued ability to oxidize it. His recent work has led Macleod2 to advocate glyconeogenesis from fat and to take that view of the diabetic disturbance which such a conclusion implies. Other

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