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August 9, 1930


JAMA. 1930;95(6):427. doi:10.1001/jama.1930.02720060045023

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The Complement Fixation Test in Leprosy  Drs. J. M. Gomes and P. C. de Azevedo Antunes recently published an article on the sensitization of lepers by means of the administration of potassium iodide as a preliminary proceeding to a serologic reaction for the early diagnosis of leprosy. For three years, they have been doing the complement fixation test, using as antigen Deycke's defatted bacillus. The test is so specific that even in atypical or incipient cases of leprosy it is satisfactory. However, in some cases of clinical leprosy negative results were obtained. In view of Muir's article on the iodide sedimentation test in leprosy, the authors endeavored to sensitize lepers by means of the oral administration of potassium iodide. About a week later, they withdrew blood for the test. The reaction caused interesting results. The patients were placed, according to the results of the test, into the following four groups:

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