Each year JAMA receives many manuscripts that report a relationship between use of a drug, device, or vaccine and adverse outcomes, as well as manuscripts that refute previously reported relationships. Some of the criteria these reports must meet to be considered for publication include that the results must be determined likely to be valid following internal evaluation and external peer review; the findings must be considered novel or consistent with a previously reported biologically plausible relationship; and the issue the study addresses must be important, including assessment of factors such as the prevalence of use of the product, severity of the adverse events, and potential implications for public health.
Fontanarosa PB, Bauchner H, Golub RM. Evaluating Research on the Safety of Medical TherapiesThe Responsibility of Journals to the Health of the Public. JAMA. 2015;314(3):235-236. doi:10.1001/jama.2015.8232