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Comment & Response
July 21, 2015

Single-Gene Genotyping and Personalized Preventive Care

Author Affiliations
  • 1King’s College London, London, England
JAMA. 2015;314(3):297-298. doi:10.1001/jama.2015.6218

To the Editor Dr Nan and colleagues1 demonstrated that the risk reduction for colorectal cancer afforded by regular use of aspirin (or other nonsteroidal anti-inflammatory drugs [NSAIDs]) was significantly associated with a single-nucleotide polymorphism (SNP) located on chromosome 12p12.3.

They concluded that validation in “additional populations may facilitate targeted colorectal cancer prevention strategies.” The accompanying Editorial2 goes further, citing the study as evidence that SNP (DNA analysis) testing can guide individualized prescription of long-term advice aimed at preventing disease. There are several caveats to these interpretations.

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