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Comment & Response
July 21, 2015

Single-Gene Genotyping and Personalized Preventive Care—Reply

Author Affiliations
  • 1Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis
  • 2Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
  • 3Division of Gastroenterology, Massachusetts General Hospital, Boston
JAMA. 2015;314(3):298. doi:10.1001/jama.2015.6233

In Reply Dr Timmons raises several important issues. First, he suggests that the differential response to aspirin or NSAIDs observed among 4% of the study participants with the rs2965667 TA or AA genotype (n = 722) may be attributable to chance. However, we used a stringent P value threshold to determine significance of an interaction between genotype and aspirin or NSAID use (P < 5 × 10−8). This threshold accounts for multiple testing (0.05/1 000 000) based on the estimated 1 000 000 independent common genetic variants in populations of European descent.1,2

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