In Reply Dr Timmons provides a compelling argument that using genetic information to guide clinical decisions about the prevention of chronic illnesses, including gene-environment interactions, is complex, requiring far more synthesis of multiple inputs than genotyping alone. I agree.
The findings of the study by Nan et al1 require validation, and as I attempted to illustrate in my Editorial, even with validation, knowing how to use the information to guide patient decisions would still require complex decision making, considering individual risk for multiple illnesses and complications of therapy.
Wender RC. Single-Gene Genotyping and Personalized Preventive Care—Reply. JAMA. 2015;314(3):298-299. doi:10.1001/jama.2015.6236