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August 16, 1930


Author Affiliations

From the Institute of Cancer Research, Columbia University, F. C. Wood, Director.

JAMA. 1930;95(7):473. doi:10.1001/jama.1930.02720070011006

The possibility of a relationship between the suprarenal cortex and the growth of malignant neoplasms has recently become a prominent subject of inquiry. Sokoloff1 has recorded the absorption of transplanted animal tumors after they had been injected with a preparation of cortex and an iron salt through which the gland was assumed to direct metabolism. Arloing, Josserand and Charachon2 have described an inhibition of the growth of a mouse carcinoma after the subcutaneous introduction of suprarenal gland from a rabbit prepared by inoculations of the same tumor; they2 found a glycerinated extract equally effective, whereas the normal gland proved to be inert, whether extracted or not. Activity was referred by these authors also to the cortex. Coffey and Humber,3 finally, have said that an extract of suprarenal cortex from the sheep causes sloughing and ultimate disappearance of malignant tumors in man, but they regarded their investigation

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