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To the Editor:
—In going over the reply to the inquiry on this subject (The Journal, February 6, p. 437), it seems to me that your answer is somewhat confusing. I was particularly interested in it, as the quotation from Tice's Practice of Medicine evidently is not taken from the last edition. The dosage given in the quotation is not intended for use in the tuberculin test but in treatment.In the last article on pulmonary tuberculosis, which Dr. Hayes and I revised, a different dose is suggested. I am inclined to believe that your quotation from Koch refers to a typical reaction occurring in a patient who has definite tuberculosis and not the reaction that might possibly occur in a normal and healthy person. If the normal and healthy person is young, no reaction whatever will, of course, occur even to 1 cc. of tuberculin. Koch, I think, states
Brown L. "REACTION OF NORMAL PERSON TO TUBERCULIN". JAMA. 1926;86(12):891. doi:10.1001/jama.1926.02670380081033