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Article
March 20, 1926

"FALLACIES OF THE 'YEAST METHOD' OF DETECTING GLUCOSE IN THE URINE"

JAMA. 1926;86(12):892. doi:10.1001/jama.1926.02670380082035

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Abstract

To the Editor:  —In The Journal, February 20, there is a paper by Drs. Aldo Castellani and F. A. Taylor, entitled "Fallacies of the 'Yeast Method' of Detecting Glucose in the Urine," which begins with the sentence: "In several of the best known manuals of pathology and clinical methods, it is stated that the fermentation test by means of yeast is the only absolutely certain and specific test for glucose." This statement is correct, excepting that "sugar" should be substituted for the word "glucose." The authors mention experiments demonstrating that yeast ferments with gas formation not only glucose but also levulose, maltose, galactose and saccharose. Then they say: "When urine is fermented by bakers' yeast, we cannot therefore come definitely to the conclusion that the fermentable substance is glucose; it might be galactose, maltose or other sugars. To detect glucose, recourse should be made to the really specific germs for

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