"The history of anemia treatment with drugs is indeed a tale to make the judicious grieve." These are the words that Whipple and Robscheit-Robbins1 used in discussion of their studies of blood regeneration. A multitude of drugs, they continue, have been proposed, enthusiastically supported, then questioned, and finally abandoned. On the whole, iron seems to enjoy the most constant favor by practicing physicians. Yet there are many good reasons for past and present misconceptions. Clinical control of patients is difficult and the number of variables almost infinity; therefore it need not surprise the critic to find that there have been differences of opinion relating to the influence of various drugs on various anemic conditions. Diet factors, Whipple and Robscheit-Robbins add further, are only recently coming in for proper study and consequent appreciation.
The most striking feature of this aspect of the subject is the demonstration now furnished by various
IRON AND BLOOD REGENERATION. JAMA. 1926;86(14):1075–1076. doi:10.1001/jama.1926.02670400085014