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The second volume of this handbook of pediatrics is devoted almost exclusively to a consideration of infectious diseases. Prof. Bela Schick contributes the first article, on diphtheria. This paper is carefully prepared, well illustrated, and that part of the chapter which is devoted to the use of antitoxin is well worth careful reading. Schick's studies on this subject have shown that in the mild cases of diphtheria a patient requires only 100 units of antitoxin for every kilogram of body weight, though in this dose the serum produces immunity, not cure. In the severer forms, the dose should be increased to 500 units of antitoxin per kilogram of body weight. Thus, a child who weighs 20 kg. (44 pounds) should receive 10,000 antitoxin units. This dosage will neutralize the toxins that have been formed twelve hours previous to injection. Furthermore, Schick thinks that the antitoxin acts by diminishing virulence, though
Handbuch der Kinderheilkunde. Ein Buch für den praktischen Arzt.. JAMA. 1924;82(25):2075. doi:10.1001/jama.1924.02650510075030