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May 1, 1926


JAMA. 1926;86(18):1351-1352. doi:10.1001/jama.1926.02670440025013

The manifestations of disease associated with an abnormally high content of sugar in the blood have long been the subject of serious experimental and clinical investigation, particularly in diabetes. If the development of scientific technic, notably micro-analysis of the blood, may be regarded as most largely responsible for the interest in hyperglycemia, it is probable that the study of the effects of insulin in the body has awakened an interest in the reverse condition of hypoglycemia. An unduly lowered level of circulating glucose in the blood is likely to be attended by characteristic symptoms often of menacing severity. Normal health thus seems to be concerned in no small measure with steering a path between the Scylla of hyperglycemia and the Charybdis of hypoglycemia.

In some respects the relationship between the blood sugar level and the appearance of symptoms is the same in various species.1 Convulsive seizures occur when the

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